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The outcome of IHE initiatives is providing better information for developing health policy and best medical practices. IHE disseminates information in many ways. In addition to publications in peer-reviewed journals, IHE produces books and a variety of reports synthesizing information in a particular field.

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Results for: Journal Articles

Agreement among the Productivity Components of Eight Presenteeism Tests in a Sample of Health Care Workers

December 05, 2017

| Angus Thompson, Arianna Waye

Presenteeism (reduced productivity at work) is thought to be responsible for large economic costs. Nevertheless, much of the research supporting this is based on self-report questionnaires that have not been adequately evaluated.

The Economic Contribution of Industry-Sponsored Pharmaceutical Clinical Trials

November 20, 2017

| Dat Tran, Ilke Akpinar, Richard Fedorak, Egon Jonsson, John Mackey, Lawrence Richer, Philip Jacobs

Purpose: In pharmaceutical clinical trials, industrial sponsors pay for study drugs and related healthcare services. We conducted a study to determine industry’s economic contribution of these trials to the Alberta healthcare system. Authors and Affiliations: Dat T. Tran1,2; Ilke Akpinar2 ; Richard N. Fedorak3 ; Egon Jonsson2 ; John R. Mackey4 ; Lawrence Richer5 ; Philip…

ERAS - Value based surgery

September 06, 2017

| Olle Ljungqvist, Thanh Nguyen, Gregg Nelson

This paper reviews implementation of enhanced recovery after surgery (ERAS) and its financial implications. Literature on clinical outcomes and financial implications were reviewed. Reports from many different surgery types shows that implementation of ERAS reduces complications and shortens hospital stay. These improvements have major impacts on reducing the cost of care even…

Benefit of adjunct universal rectal screening for Chlamydia genital infections in women attending Canadian sexually transmitted infection clinics

May 23, 2017

| Thanh Nguyen, Ilke Akpinar, Jennifer Gratrix, Sabrina Plitt, Petra Smyczek, Ron Read, Philip Jacobs, Tom Wong, Ameeta E Singh

Adding universal rectal screening to urogenital screening should positively impact rectal Chlamydia trachomatis (CT) incidence in affected populations. A dynamic Markov model was used to evaluate costs and outcomes of three rectal CT screening strategies among women attending sexually transmitted infection clinics in Alberta, Canada: universal urogenital-only screening (UG-only),…

The Case for a Federal Mental Health Transition Fund

January 05, 2017

| Alain Lesage, Roger Bland, Ian Musgrave, Egon Jonsson, Mike Kirby, Helen-Maria Vasiliadis

The Liberal government committed to making mental health services more accessible. Housing funding was increased in the last budget, but now commitment to comprehensive home care for the severely mentally ill and access to primary care treatments for common mental disorders are needed.

The economic burden of inadequate consumption of vegetables and fruit in Canada

December 16, 2016

| John Paul Ekwaru, Arto Ohinmaa, Sarah Loehr, Solmaz Setayeshgar, Thanh Nguyen, Paul J Veugelers

Objective: Public health decision makers not only consider health benefits but also economic implications when articulating and issuing lifestyle recommendations. Whereas various estimates exist for the economic burden of physical inactivity, excess body weight and smoking, estimates of the economic burden associated with our diet are rare. In the present study, we estimated the…

Forecasting Pharmaceutical Prices for Economic Evaluations When There Is No Market: A Review

November 08, 2016

| Ilke Akpinar, Philip Jacobs, Tien Dat Tran

Economic evaluation helps policy makers and healthcare payers make decisions on drug listing, coverage, and reimbursement. When economic evaluations are conducted before a product launch, the prices of the pharmaceuticals have to be forecast.

An economic evaluation of the Enhanced Recovery After Surgery (ERAS) multisite implementation program for colorectal surgery in Alberta

October 17, 2016

| Thanh Nguyen, Anderson Chuck, Tracy Wasylak, Jeannette Lawrence, Peter Faris, Olle Ljungqvist, Gregg Nelson, Leah Gramlich

  BACKGROUND: In February 2013, Alberta Health Services established an Enhanced Recovery After Surgery (ERAS) implementation program for adopting the ERAS Society colorectal guidelines into 6 sites (initial phase) that perform more than 75% of all colorectal surgeries in the province. We conducted an economic evaluation of this initiative to not only determine its cost-effectiveness,…

Trends and Regional Variation in Hospital Mortality, Length of Stay and Cost in Hospital of Ischemic Stroke Patients in Alberta Accompanying the Provincial Reorganization of Stroke Care

September 26, 2016

| Arto Ohinmaa, Yufei Zheng, Thomas Jeerakathil, Scott Klarenbach, Unto Häkkinen, Thanh Nguyen, Dan Friesen, Jane Ruseski, Padma Kaul, Ruolz Ariste, Philip Jacobs

  OBJECTIVES: This study aimed to evaluate the trends and regional variation of stroke hospital care in 30-day in-hospital mortality, hospital length of stay (LOS), and 1-year total hospitalization cost after implementation of the Alberta Provincial Stroke Strategy.

Cost Effectiveness of Eplerenone for the Treatment of Systolic Heart Failure with Mild Symptoms in Alberta, Canada

June 14, 2016

| Thanh Nguyen, Justin Ezekowitz, Dat Tran, Padma Kaul

  BACKGROUND: Eplerenone has been demonstrated as being cost effective for the treatment of patients with systolic heart failure (HF) and mild symptoms in several jurisdictions; however, its cost effectiveness is unknown in the context of Alberta, Canada.

Mental health services costs within the Alberta criminal justice system

May 26, 2016

| Alain Lesage, Carolyn Dewa, Jessica Moffatt, Philip Jacobs, Thanh Nguyen, Ting Zhang

  Objective: The objective of this paper is to estimate the additional mental health service costs incurred within the criminal justice system that are incurred because of people with mental illnesses who go through the system. Our focus is on costs in Alberta.

Post-Policy Implementation Review of Rapid Fetal Fibronectin (fFN) Testing for Preterm Labour in Alberta

May 12, 2016

| Anderson Chuck, Thanh Nguyen, James Wesenberg, Rhada Chari, Robert Wilson, Selikke Janes-Kelley

Objectives: In 2006, the Alberta Ministry of Health issued a policy to implement fetal fibronectin (fFN) testing as a publicly funded service for pregnant women. The goals were to reduce maternity health care utilization and unnecessary treatment, which would result in cost-savings for the health system by more accurately diagnosing false preterm labour. We conducted a post-policy…

Life expectancy of people with Fetal Alcohol Syndrome.

March 09, 2016

| Thanh Nguyen, Egon Jonsson

  Objectives: To estimate the life expectancy and specify the causes of death among people with fetal alcohol syndrome (FAS). Methods: Included were all patients recorded in Alberta provincial databases of inpatients, outpatients, or practitioner claims from 2003 to 2012. People with FAS were identified by ICD-9 code 760.71 and ICD-10 codes Q86.0 and P04.3, and were linked…

Health services utilization of people having and not having a regular doctor in Canada

February 10, 2016

| Thanh Nguyen, John Rapoport

  Abstract: Canada having a universal health insurance plan that provides hospital and physician benefits offers a natural experiment of whether continuity ofcare actually provides lower or higher utilization of services. The question we are evaluating is whether Canadians, who have a regular physician, use more health resources than those who do not have one? Using two statistical…

Palliative care costs in Canada: A descriptive comparison of studies of urban and rural patients near end of life

December 07, 2015

| Serge Dumont, Philip Jacobs, Véronique Turcotte, Stéphane Turcotte, Grace Johnston

  Background: Significant gaps in the evidence base on costs in rural communities in Canada and elsewhere are reported in the literature, particularly regarding costs to families. However, it remains unclear whether the costs related to all resources used by palliative care patients in rural areas differ to those resources used in urban areas.

Value Added by the Prevnar 13 Childhood Immunization Program in Alberta, Canada (2010–2015)

September 30, 2015

| Arianna Waye, Anderson Chuck

Objective: In this study, we estimate the impact of the new PCV13 immunization program on the burden of disease and related healthcare costs in Alberta.

Health Service Use and Costs Associated with Low Birth Weight – A Population Level Analysis

September 01, 2015

| Thanh Nguyen, Jennifer Toye, Anamaria Savu, Manoj Kumar, Padma Kaul

  OBJECTIVES: To examine differences in health services utilization (HSU) costs in the first year of life between low birth weight (LBW) and normal birth weight (NBW) infants, identify maternal and child characteristics associated with HSU costs, and estimate annual HSU cost of LBW infants for the province of Alberta, Canada.

A principal component analysis is conducted for a case series quality appraisal checklist

August 22, 2015

| Bing Guo, Carmen Moga, Christa Harstall, Don Schopflocher

  Objective: Because of a lack of a control group, a case-series study is considered one of the weaker study designs from which to obtain evidence on treatment effectiveness. Under certain circumstances, however, this is the only available evidence to inform health-care decisions. This study's intent was to develop and validate a quality appraisal checklist specifically for…

Guideline for primary care management of headache in adults

August 15, 2015

| Werner J Becker, Ted Findlay, Carmen Moga, Ann Scott, Christa Harstall, Paul Taenzer

  Objective: To increase the use of evidence-informed approaches to diagnosis, investigation, and treatment of headache for patients in primary care. Note: This is an Alberta Ambassador Guideline Adaptation Program related publication.

Costs of Fetal Alcohol Spectrum Disorder in the Canadian Criminal Justice System

June 15, 2015

| Thanh Nguyen, Egon Jonsson

  We reviewed literature to estimate the costs of Fetal Alcohol Spectrum Disorder (FASD) in the Canadian Criminal Justice System (CJS), and to update the total costs of FASD in Canada. The results suggest FASD is costlier than previous estimates. The costs of FASD associated with the CJS are estimated at $3.9 billion a year, with $1.2 billion for police, $0.4 billion for court,…

Supporting the Use of Health Technology Assessments by Decision-Makers.

May 29, 2015

| Julie Polisena, John Lavis, Don Juzwishin, Pam McLean-Veysey, Ian Graham, Christa Harstall, Janet Martin

  A perceived gap exists in how well Canadian health technology assessment (HTA) producers are supporting the use of their HTAs by decision-makers. The authors propose that the newly released HTA Database Canadian search interface incorporate structured decision-relevant summaries of HTAs that would be developed by participating Canadian HTA organizations. The registry would…

Medical Device Prices in Economic Evaluations.

May 20, 2015

| Ilke Akpinar, Philip Jacobs, Don Husereau

  Objectives: Economic evaluations, although not formally used in purchasing decisions for medical devices in Canada, are still being conducted and published. The aim of this study was to examine the way that prices have been included in Canadian economic evaluations of medical devices.

A systematic review of measurement properties of instruments assessing presenteeism.

February 01, 2015

| Maria Ospina, Liz Dennett, Arianna Waye, Philip Jacobs, Angus Thompson

  Objectives: To assess and compare the measurement properties (ie, validity, reliability, responsiveness) and the quality of the evidence of presenteeism instruments.

An economic evaluation of the parent-child assistance program for preventing fetal alcohol spectrum disorder in Alberta, Canada.

January 30, 2015

| Thanh Nguyen, Egon Jonsson, Jessica Moffatt, Liz Dennett, Anderson Chuck, Shelley Birchard

  Abstract: Parent-Child Assistance Program (P-CAP) is a 3-year home visitation/harm reduction intervention to prevent alcohol exposed births, thereby births with fetal alcohol spectrum disorder, among high-risk women. This article used a decision analytic modeling technique to estimate the incremental cost-effectiveness ratio and the net monetary benefit of the P-CAP within…

Implementing the Resource in Clinic Program in primary care delivery: a team-based dyad approach.

January 12, 2015

| Lindsay Wodinski, Kate Woodman, Margaret Wanke, Thanh Nguyen, Philip Jacobs

  Abstract: Alberta's Primary Care Networks (PCNs) bring together family physicians and other health professionals to provide local, comprehensive, and readily accessible primary care services to patients. The Edmonton North PCN, one of the largest in the province, piloted the Resource in Clinic (RIC) Program with objectives to increase efficiencies in the use of physician…

Medical tourism and bariatric surgery: who pays?

December 08, 2014

| Caroline Sheppard, Erica Lester, Anderson Chuck, David Kim, Shahzeer Karmali, Christopher Gara, Daniel Birch

  INTRODUCTION: The objective of this study was to determine the short-term cost impact thatmedical tourism for bariatric surgery has on a public healthcare system. Due to long wait times for bariatric surgery services, Canadians are venturing to private clinics in other provinces/countries. Postoperative care in this population not only burdens the provincial health system…

Costs of health services utilization of people with fetal alcohol spectrum disorder by sex and age group in Alberta, Canada.

November 17, 2014

| Thanh Nguyen, Egon Jonsson

  Objectives: To estimate the annual health services utilization (HSU) cost per person with FASD by sex and age; the lifetime HSU cost per person with FASD by sex, and the annual HSU cost of FASD for Alberta by sex.

Real-life treatment paradigms show infliximab is cost-effective for management of ulcerative colitis

November 12, 2014

| Victoria Ung, Thanh Nguyen, Karen Wong, Karen Kroeker, Thomas Lee, Haili Wang, Arto Ohinmaa, Philip Jacobs, Richard Fedorak

  BACKGROUND & AIMS: Infliximab is effective for induction and maintenance of response in patients with moderate to moderately severe ulcerative colitis. Previous cost analyses of infliximab treatment for ulcerative colitis used models of colectomy vs infliximab and response rates derived from early clinical trials. In real life, therapeutic options are more complex; patients…

Incidence and prevalence of fetal alcohol spectrum disorder by sex and age group in Alberta, Canada.

October 29, 2014

| Thanh Nguyen, Egon Jonsson, Amy Salmon, Meghan Sebastianski

  Objectives: To estimate incidence and prevalence of FASD by sex and age in Alberta, Canada.

How do economic evaluations inform health policy decisions for treatment and prevention in Canada and the United States?

October 15, 2014

| Don Husereau, Anthony Culyer, Peter Neumann, Philip Jacobs

  Abstract: Canadian and US health systems have often been characterized as having vastly different approaches to the financing and delivery of healthcare, with Canada portrayed as more reliant on rationing based on costs. In this article, we examine the similarities and differences between the two countries, the evolution and current role of health economic evaluation, and…

Canadian estimates of health care utilization costs for rheumatoid arthritis patients with and without therapy with biologic agents

September 01, 2014

| Arto Ohinmaa, Thanh Nguyen, Cheryl Barnabe, Liam Martin, Anthony Russell, Susan G Barr, Walter Maksymowych

  OBJECTIVE: To provide Canadian estimates of health care utilization costs associated withrheumatoid arthritis (RA)-related and non-RA-related care within 4 treatment strategies and in different physical functioning categories.

Effect of remission definition on healthcare cost savings estimates for patients with rheumatoid arthritis treated with biologic therapies.

August 04, 2014

| Cheryl Barnabe, Thanh Nguyen, Arto Ohinmaa, Joanne Homik, Susan G Barr, Liam Martin, Walter Maksymowych

  OBJECTIVE: Sustained remission in rheumatoid arthritis (RA) results in healthcare utilizationcost savings. We evaluated the variation in estimates of savings when different definitions ofremission [2011 American College of Rheumatology/European League Against Rheumatism Boolean Definition, Simplified Disease Activity Index (SDAI) ≤ 3.3, Clinical Disease Activity Index…

How does burnout affect physician productivity? A systematic literature review

July 28, 2014

| Carolyn Dewa, Desmond Loong, Sarah Bonato, Thanh Nguyen, Philip Jacobs

  BACKGROUND: Interest in the well-being of physicians has increased because of their contributions to the healthcare system quality. There is growing recognition that physicians are exposed to workplace factors that increase the risk of work stress. Long-term exposure to high work stress can result in burnout. Reports from around the world suggest that about one-third to…

An estimate of the cost of burnout on early retirement and reduction in clinical hours of practicing physicians in Canada

June 13, 2014

| Carolyn Dewa, Philip Jacobs, Thanh Nguyen, Desmond Loong

  BACKGROUND: Interest in the impact of burnout on physicians has been growing because of the possible burden this may have on health care systems. The objective of this study is toestimate the cost of burnout on early retirement and reduction in clinical hours of practicingphysicians in Canada.

Should vitamin B12 tablets be included in more Canadian drug formularies?

May 02, 2014

| Sherilyn Houle, Michael Kolber, Anderson Chuck

  Should vitamin B12 tablets be included in more Canadian drug formularies? An economic model of the cost-saving potential from increased utilisation of oral versus intramuscular vitamin B12 maintenance therapy for Alberta seniors. OBJECTIVE: The aim of this study was to estimate the cost-savings attainable if all patients aged ≥65 years in Alberta, Canada, currently on…

Value of databases other than medline for rapid health technology assessments

April 30, 2014

| Diane Lorenzetti, Leigh-Ann Topfer, Liz Dennett, Fiona Clement

  OBJECTIVES: The objective of this study was to explore the degree to which databases otherthan MEDLINE contribute studies relevant for inclusion in rapid health technology assessments (HTA).

The international charter on prevention of fetal alcohol spectrum disorder

March 01, 2014

| Egon Jonsson, Amy Salmon, Kenneth Warren

  The International Charter on Prevention of FASD has been published in The Lancet Global Health, one of the world’s most influential public-health journals.  The Charter – also known as the “Edmonton Charter” – was endorsed at the First International Conference on Prevention of FASD in September 2013.The Edmonton Charter was drafted by senior…

The international charter on prevention of fetal alcohol spectrum disorder – French Translation

March 01, 2014

| Egon Jonsson, Amy Salmon, Kenneth Warren

The International Charter on Prevention of FASD has been published in The Lancet Global Health, one of the world’s most influential public-health journals. The Charter – also known as the “Edmonton Charter” – was endorsed at the First International Conference on Prevention of FASD in September 2013.The Edmonton Charter was drafted by senior staff of…

The international charter on prevention of fetal alcohol spectrum disorder – Japanese Translation

March 01, 2014

| Egon Jonsson, Amy Salmon, Kenneth Warren

The International Charter on Prevention of FASD has been published in The Lancet Global Health, one of the world’s most influential public-health journals. The Charter – also known as the “Edmonton Charter” – was endorsed at the First International Conference on Prevention of FASD in September 2013.The Edmonton Charter was drafted by senior staff of…

The international charter on prevention of fetal alcohol spectrum disorder – Portuguese Translation

March 01, 2014

| Egon Jonsson, Amy Salmon, Kenneth Warren

The International Charter on Prevention of FASD has been published in The Lancet Global Health, one of the world’s most influential public-health journals. The Charter – also known as the “Edmonton Charter” – was endorsed at the First International Conference on Prevention of FASD in September 2013.The Edmonton Charter was drafted by senior staff of…

The international charter on prevention of fetal alcohol spectrum disorder – Russian Translation

March 01, 2014

| Egon Jonsson, Amy Salmon, Kenneth Warren

The International Charter on Prevention of FASD has been published in The Lancet Global Health, one of the world’s most influential public-health journals. The Charter – also known as the “Edmonton Charter” – was endorsed at the First International Conference on Prevention of FASD in September 2013.The Edmonton Charter was drafted by senior staff of…

The international charter on prevention of fetal alcohol spectrum disorder – Swahili Translation

March 01, 2014

| Egon Jonsson, Amy Salmon, Kenneth Warren

The International Charter on Prevention of FASD has been published in The Lancet Global Health, one of the world’s most influential public-health journals. The Charter – also known as the “Edmonton Charter” – was endorsed at the First International Conference on Prevention of FASD in September 2013.The Edmonton Charter was drafted by senior staff of…

The international charter on prevention of fetal alcohol spectrum disorder – Chinese Translation

March 01, 2014

| Egon Jonsson, Amy Salmon, Kenneth Warren

The International Charter on Prevention of FASD has been published in The Lancet Global Health, one of the world’s most influential public-health journals. The Charter – also known as the “Edmonton Charter” – was endorsed at the First International Conference on Prevention of FASD in September 2013.The Edmonton Charter was drafted by senior staff of…

Health Policy Analysis: A Synthesis of Drug Reimbursement Decision-Making Processes in Organisation for Economic Co-operation and Development Countries

February 17, 2014

| Lianne Barnieh, Braden Manns, Anthony Harris, Marja Blom, Cam Donaldson, Scott Klarenbach, Don Husereau, Diane Lorenzetti, Fiona Clement

  BACKGROUND: The use of a restrictive formulary, with placement determined through a drug-reimbursement decision-making process, is one approach to managing drug expenditures.

Vaccine development costs: a review

December 02, 2013

| Arianna Waye, Philip Jacobs, Anthony Schryvers

    Abstract: The cost of drug development is commonly cited between US$800 and US$1.8 billion. A similar statistic for vaccines is yet to be estimated, and it is unclear whether the cost of vaccines is similar to drug development. Financial and regulatory policy significantly impacts the extent and cost of pharmaceutical development, and as such it is important that…

Societal monetary benefits of pharmaceutical innovation: the case of ramipril in Canada.

December 02, 2013

| Thanh Nguyen, Anderson Chuck, Arto Ohinmaa, Philip Jacobs

Objectives: To estimate the monetary benefits of ramipril and its distribution over time among four beneficiaries in Canada: the drug developing manufacturer, generic manufacturers, the healthcare sector and employment sectors.

A systematic review of the effectiveness of knowledge translation interventions for chronic noncancer pain management.

November 01, 2013

| Maria Ospina, Paul Taenzer, Saifee Rashiq, Joy MacDermid, Eloise Carr, Dagmara Chojecki, Christa Harstall, James Henry

  Objectives: To conduct a systematic review of the effectiveness of KT interventions for chronic noncancer pain management.

Adapting low back pain guidelines within a multidisciplinary context: a process evaluation.

October 30, 2013

| Christa Harstall, Paul Taenzer, Nancy Zuck, Donna Angus, Carmen Moga, Ann Scott

  Rationale, Aims, and Objectives: The Alberta Ambassador Program (AAP) adapted seven clinical practice guidelines on low back pain (LBP) into a single guideline spanning the continuum of care from prevention and diagnosis through to treatment. The Ambassador adaptation process was evaluated to 1 Identify the major challenges encountered and successful strategies utilized;…

The impact of the universal infant varicella immunization strategy on Canadian varicella-related hospitalization rates

October 01, 2013

| Arianna Waye, Philip Jacobs, Ben Tan

  INTRODUCTION: Varicella vaccine was introduced to the infant immunization schedule in each province or territory between 2000 and 2007 as a result of the Canadian ImmunizationStrategy. The impact of vaccinating children against this disease is potentially far reaching, asimmunization may also benefit those segments of the population not immunized. The objective of this paper…

Potential impacts of the Alberta fetal alcohol spectrum disorder service networks on secondary disabilities: a cost-benefit analysis.

July 18, 2013

| Thanh Nguyen, Jessica Moffatt, Philip Jacobs, Anderson Chuck, Egon Jonsson

  Objectives: To estimate the break-even effectiveness of the Alberta Fetal Alcohol Spectrum Disorder (FASD) Service Networks in reducing occurrences of secondary disabilities associated with FASD.

Wait time from primary to specialty care: a trend analysis from Edmonton, Canada.

May 06, 2013

| Thanh Nguyen, Margaret Wanke, Leanne McGeachy

  Abstract: Medical wait time is a top health policy issue in Canada. Reliable data on the referral wait time from primary to specialty care are limited. Existing data on referral wait times are generally self-reported by specialists. In 2008, the Edmonton North Primary Care Network (PCN) developed a Centralized Referral Program, including a specialist database that contains…

Fetal alcohol spectrum disorder - poverty trap?

March 04, 2013

| Thanh Nguyen, Egon Jonsson, Jessica Moffatt, Liz Dennett

  From the Introduction: In this paper, we report a discussion of available evidence regarding the association between poverty and FASD, and regarding the economic consequences of FASD on individuals and families which may materialize an FASD - poverty trap.

Stress and development of depression and heavy drinking in adulthood: moderating effects of childhood trauma.

February 01, 2013

| Ian Colman, Yasmin Garad, Yiye Zeng, Kiyuri Naicker, Murray Weeks, Scott Patten, Peter Jones, Angus Thompson, T. Cameron Wild

  Purpose: Studies suggest that childhood trauma is linked to both depression and heavy drinking in adulthood, and may create a lifelong vulnerability to stress. Few studies have explored the effects of stress sensitization on the development of depression or heavy drinking among those who have experienced traumatic childhood events. This study aimed to determine the effect…

Does performance-based remuneration for individual health care practitioners affect patient care?: a systematic review.

December 18, 2012

| Sherilyn Houle, Finlay McAlister, Cynthia Jackevicius, Anderson Chuck, Ross Tsuyuki

  BACKGROUND: Pay-for-performance (P4P) is increasingly touted as a means to improve health care quality. PURPOSE: To evaluate the effect of P4P remuneration targeting individual health careproviders.

Long-term course and outcome in schizophrenia: a 34-year follow-up study in Alberta, Canada.

October 01, 2012

| Stephen Newman, Roger Bland, Angus Thompson

  Background: The aim of this study was to extend an earlier retrospective cohort study of schizophrenia via a prospective study to a follow-up of 34 years, with an emphasis on describing the life-course of the illness.

Benefits of pharmaceutical innovation: the case of simvastatin in Canada.

September 19, 2012

| Thanh Nguyen, Anderson Chuck, Arto Ohinmaa, Philip Jacobs

  Background: The benefits of pharmaceutical innovations are widely diffused; they accrue to the healthcare providers, patients, employers, and manufacturers. We estimate the societal monetary benefits of simvastatin in Canada and its distribution among different beneficiaries overtime.

The Distribution of Mental Health Service Costs for Depression in the Alberta Population.

September 10, 2012

| Mel Slomp, Philip Jacobs, Arto Ohinmaa, Roger Bland, Ray Block, Carolyn Dewa, Carina Wang

  OBJECTIVES: In Canada, most mental health services are embedded in the publichealth care system. Little is known of the cost distribution within the mental healthpopulation. Our study aims to estimate the depression care costs of patients with adepression diagnosis, ranking them by the increasing total depression health carecosts.

A conceptual framework identifying sources of risk to patient safety in primary care.

September 03, 2012

| Logan McLeod, JoAnn Kingston-Riechers, Egon Jonsson

  Abstract: The potential risks to patient safety in a primary care setting are different than the risks to patient safety in an acute care setting. The main differences arise from the organisational structures of primary care delivery and the greater involvement of patients in their care. To account for these differences, we present the Patient Safety in Primary Care Framework…

Effect of a pharmacist-managed hypertension program on health system costs: an evaluation of the Study of Cardiovascular Risk Intervention by Pharmacists-Hypertension (SCRIP-HTN)

June 11, 2012

| Sherilyn Houle, Anderson Chuck, Finlay McAlister, Ross Tsuyuki

  STUDY OBJECTIVE: To quantify the potential cost savings of a community pharmacy-basedhypertension management program based on the results of the Study of Cardiovascular Risk Intervention by Pharmacists-Hypertension (SCRIP-HTN) study in terms of avoided cardiovascular events-myocardial infarction, stroke, and heart failure hospitalization, and to compare these cost savings…

Changes in drug use are associated with health-related quality of life improvements among methadone maintenance patients with HIV/AIDS.

May 07, 2012

| Bach Tran, Arto Ohinmaa, Anh Duong, Nhan Do, Long Nguyen, Quoc Nguyen, Steve Mills, Philip Jacobs, Stan Houston

  PURPOSE: This longitudinal study assessed the changes in drug use patterns and health-related quality of life (HRQL) among HIV-positive drug users in the first methadonemaintenance treatment (MMT) cohort in Vietnam.

What Do We Know About Knowledge Translation in the Care of Older Adults? A Scoping Review.

March 05, 2012

| Anne-Marie Boström, Susan E Slaughter, Dagmara Chojecki, Carole Estabrooks

  OBJECTIVES: The recent emphasis on knowledge translation (KT) in health care is based on the premise that quality of care improves when research findings are translated into practice. This study aimed to identify the extent, nature, and settings of KT research pertaining to the care of older adults.

Systematic review: faecal transplantation for the treatment of Clostridium difficile-associated disease.

February 23, 2012

| Bing Guo, Christa Harstall, Thomas Louie, Sander Veldhuyzen van Zanten, Levinus Dieleman

  Aim: To critically appraise the clinical research evidence on the safety and effectiveness of FT compared with standard care in the treatment of patients with CDAD.

Childhood depression revisited: indicators, normative tests, and clinical course.

February 06, 2012

| Angus Thompson

  From the Introduction: Until four or five decades ago, the clinical consensus about childhood depression was that it did not, and perhaps could not, occur (Lefkowitz & Burton, 1978; Rie, 1966; Rochlin, 1965; Wolfenstein, 1966). In fact, prior to 1960, childhood depression was rarely mentioned in the literature (Cytryn, 2003; Tisher, 2007). A number of studies and conceptualizations…

Everybody’s business: economic surveillance of public health services in Alberta, Canada

December 13, 2011

| Philip Jacobs, Jessica Moffatt, Arto Ohinmaa, Egon Jonsson

  Background: To address public health risk factors, governments conduct interventions in many different ministries, including non-health ministries. In order to understand the scope and cost of public health in Alberta, we developed a survey of government public health interventions. We included any government ministry or public organization, which includes health as a stated…

The Association of Treatment of Depressive Episodes and Work Productivity.

December 12, 2011

| Carolyn Dewa, Angus Thompson, Philip Jacobs

  OBJECTIVE: About one-third of the annual $51 billion cost of mental illnesses is related toproductivity losses. However, few studies have examined the association of treatment andproductivity. The purpose of our research is to examine the association of depression and itstreatment and work productivity.

Are economic evaluations an important tool in vaccine policy decisions?

October 10, 2011

| Philip Jacobs

  Abstract: In the 1980s, drug prices began rising considerably worldwide, and in the 1990s, countries began incorporating health economics into the scientific review process. Rising prices in vaccines began around the year 2000 and national bodies began to use health economics to review vaccines in the next decade. Health economics is a discipline that evaluates alternative…

The suicidal process: age of onset and severity of suicidal behaviour.

September 21, 2011

| Angus Thompson, Carolyn Dewa, Stephanie Phare

  Purpose: The concept of the suicidal process implies a progression from behaviour of relatively low intent to completed suicide. Evidence from the literature has given rise to the speculation that the age of onset of an early form of the suicidal process may be associated with the ultimate seriousness of suicidal behaviour. This study was designed to test the hypothesis…

Creating a multidisciplinary low back pain guideline: anatomy of a guideline adaptation process.

August 30, 2011

| Christa Harstall, Paul Taenzer, Donna Angus, Carmen Moga, Ann Scott, Tara Schuller

  Rationale, Aims, and Objectives: A collaborative, multidisciplinary guideline adaptation process was developed to construct a single overarching, evidence-based clinical practice guideline (CPG) for all primary care practitioners responsible for the management of low back pain (LBP) to curb the use of ineffective treatments and improve patient outcomes. Note: This is an…

Treatment for convicted adult male sex offenders: an overview of systematic reviews

January 01, 2011

| Paula Corabian, Liz Dennett, Christa Harstall

This article is an overview of systematic reviews reporting on the efficacy/effectiveness of psychotherapy and/or pharmacotherapy interventions delivered within Sex Offender Treatment (SOT) programs to reduce the risk of re-offending in convicted adult male sex offenders. Related Report: Treatment for Convicted Adult Male Sex Offenders

Managing low back pain in the primary care setting: the know-do gap.

November 30, 2010

| Ann Scott, Carmen Moga, Christa Harstall

  Objective: To ascertain knowledge gaps in the diagnosis and treatment of acute and chronic low back pain (LBP) in the primary care setting to prepare a scoping survey for identifying knowledge gaps in LBP management among Alberta's primary care practitioners, and to identify potential barriers to implementing a multidisciplinary LBP guideline. Note: This is an Alberta Ambassador…

Improving reliability of the assessment of the life course of schizophrenia

November 08, 2010

| Angus Thompson, Stephen Newman, Helene Orn, Roger Bland

  OBJECTIVE: Life course studies of schizophrenia that have used a 3-phase model (onset,course, and outcome) have had their use restricted owing to differences in definition and methodology. The purpose of this investigation was to describe life course data in mathematical terms and to compare the results with the findings from other life course studies.

Cost of Mental Health Services in Alberta Schools

October 29, 2010

| Peter Calder, Dick Sobsey, Philip Jacobs

Abstract: Within the school system, children with mental illness receive a variety of services that arise because of their conditions, and that require resources that exceed those provided to other students. Some of these services fall into the category of "specialized mental health" services, while others are additional services provided by teachers as part of their routine activities.…

Sources of revenue for nonprofit mental health and addictions organizations in Canada.

October 01, 2010

| Carissa Escober-Doran, Philip Jacobs, Carolyn Dewa

  Objective: In Canada charitable or nonprofit organizations provide government-contracted mental health and addictions services, and they augment government funding by raising charitable revenues. This study estimated by source the revenues of nonprofit mental health and addictions organizations in Canada.

Drinking alcohol during pregnancy: evidence from Canadian Community Health Survey 2007/2008.

August 17, 2010

| Thanh Nguyen, Egon Jonsson

  Objectives: To estimate the prevalence of drinking alcohol during pregnancy and examine the determinants of this behaviour.

Outcomes of the introduction of the MOREOB continuing education program in Alberta.

August 09, 2010

| Thanh Nguyen, Philip Jacobs, Margaret Wanke, Ann Hense, Reg Sauve

  OBJECTIVE: In 2004, the three-module, three-year long patient safety program, Managing Obstetrical Risk Efficiently (MOREOB), was introduced to all clinicians providing obstetrical services in Alberta. We report on an outcomes evaluation of this initiative.

Health Technology Assessment and Comparative Effectiveness in Sweden

July 12, 2010

| Egon Jonsson

  Abstract: The article presents information on the Health Technology Assessment. Guidance for health care practices in Sweden were documented when Medical Collegium was established in 1663 to distinguish quackery from medicine and control the poisonous drugs. In early 1980s, Sweden established the Swedish Council on Technology Assessment in Healthcare to assess major diseases…

Tackling ethical issues in health technology assessment: A proposed framework

July 05, 2010

| Amanda Burls, Lorraine Caron, Ghislaine Cleret de Langavant, Wybo Dondorp, Christa Harstall, Ela Pathak-Sen, Bjørn Hofmann

  OBJECTIVES: Values are intrinsic to the use of health technology assessments (HTAs) inhealth policy, but neglecting value assumptions in HTA makes their results appear more robust or normatively neutral than may be the case. Results of a 2003 survey by the International Network of Agencies for Health Technology Assessment (INAHTA) revealed the existence of disparate methods…

Cost-effectiveness of 21 alternative cervical cancer screening strategies.

April 12, 2010

| Anderson Chuck

  OBJECTIVES: The aim of this study is to assess the cost-effectiveness of 21 alternativecervical cancer screening (CCS) strategies.

Routine preoperative electrocardiogram and chest x-ray prior to elective surgery in Alberta, Canada

February 08, 2010

| Thanh Nguyen, Saifee Rashiq, Egon Jonsson

  PURPOSE: A study was undertaken to evaluate the utilization rates of routine preoperativeelectrocardiogram (ECG) and chest x-ray (CXR) by sex, age, and most frequent surgery type, and to estimate the total cost of these screening tests.

Overview of a formal scoping review on health system report cards

January 15, 2010

| Susan E Brien, Diane Lorenzetti, Steven Lewis, James Kennedy, William A Ghali

  BACKGROUND: There is an extensive body of literature on health system quality reporting that has yet to be characterized. Scoping is a novel methodology for systematically assessing the breadth of a body of literature in a particular research area. Our objectives were to showcase the scoping review methodology in the review of health system quality reporting, and to reporton…

Making the AGREE tool more user-friendly: the feasibility of a user guide based on Boolean operators.

December 30, 2009

| Ann Scott, Carmen Moga, Christa Harstall

  Rationale, aims and objectives: The Appraisal of Guidelines Research and Evaluation (AGREE) instrument is a generic tool for assessing guideline quality. This feasibility study aimed to reduce the ambiguity and subjectivity associated with AGREE item scoring, and to augment the tool's capacity to differentiate between good- and poor-quality guidelines. Note: This is an Alberta…

Costs of Fetal Alcohol Spectrum Disorder in Alberta, Canada

January 16, 2009

| Thanh Nguyen, Egon Jonsson

  Background: Although many programs targeting fetal alcohol spectrum disorder (FASD) are implemented, the province of Alberta is still lacking information on costs of FASD. Objectives: To estimate the costs of FASD in Alberta based on available US and Canadian research on costs of FASD, and Alberta data.

Using health technology assessment to identify research gaps: an unexploited resource for increasing the value of clinical research.

February 28, 2008

| Ann Scott, Carmen Moga, Christa Harstall, Jacques Magnan

  Abstract: Health technology assessments (HTAs) are an as yet unexploited source of comprehensive, systematically generated information that could be used by research funding agencies to formulate researchable questions that are relevant to decision-makers. We describe a process that was developed for distilling evidence gaps identified in HTAs into researchable questions…

Creating clinically relevant knowledge from systematic reviews: the challenges of knowledge translation.

August 30, 2007

| Ann Scott, Carmen Moga, Pamela Barton, Saifee Rashiq, Don Schopflocher, Paul Taenzer, Christa Harstall

  Rationale and objective: A research translation strategy for chronic pain was developed that has significant potential to advance the usefulness of systematic reviews (SRs) in clinical practice. Note: This is an Alberta Ambassador Guideline Adaptation Program related publication.

The Alberta Ambassador Program: delivering Health Technology Assessment results to rural practitioners.

March 31, 2006

| Saifee Rashiq, Pamela Barton, Christa Harstall, Don Schopflocher, Paul Taenzer

  Background: The purpose of Health Technology Assessment (HTA) is to make the best possible summary of the evidence regarding specific health interventions in order to influence health care and policy decisions. The need for decision makers to find relevant HTA data when it is needed is a barrier to its usefulness. These barriers are highest in rural areas and amongst isolated…

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